Small Moments Could Become Big Wins With RA Symptom Relief

XELJANZ can help relieve joint pain, swelling, and stiffness, and helps stop further joint damage.

XELJANZ is used to treat adults with moderately to severely active rheumatoid arthritis when 1 or more medicines called tumor necrosis factor (TNF) blockers have been used, and did not work well or cannot be tolerated.

XELJANZ is a pill, not an injection or infusion
pill in hand

Results From RA Clinical Trials* Prove XELJANZ Can:

Help relieve joint pain, swelling, and stiffness
Help stop further joint damage
Help some people experience RA symptom reduction within
2 weeks
Help some people feel
less RA fatigue

For others it could take up to three months or longer. Individual results may vary.

Adult patients with moderate to severe RA were evaluated in clinical trials. Some patients in the clinical studies were taking background medicines such as methotrexate and some were not. Some studies evaluated patients when other medicines such as methotrexate or TNF blockers did not work well or could not be tolerated. XELJANZ is approved for use in patients when TNF blockers did not work well or could not be tolerated.

Explore Clinical Trial Results

family at park

Picture Everyday Moments with Family and Friends


XELJANZ is a Janus kinase (JAK) inhibitor that helps regulate an overactive immune system. It helps disrupt JAK pathways from inside the cells, which are believed to play a role in inflammation.

XELJANZ helps reduce inflammation, a cause of permanent joint damage.

Molecule graphic

These images of potential disease symptoms are for illustrative purposes only and are not intended to be fully anatomically accurate.

Working With Your Doctor

If your current treatment isn't working well enough to manage your RA symptoms, it's important to have an open and honest discussion with your doctor. Every appointment is an opportunity to improve the dialogue with your doctor and discuss how to manage your RA. Ready to make an appointment? Find A Healthcare Provider near you.


Before your next appointment, get ready for the conversation by reflecting on your current treatment plan and tracking your recent symptoms. The information could be helpful in finding a treatment plan that may work best for you.


It may help make it easier to talk about if you write down any questions or concerns you may have ahead of your appointment to give your doctor a complete picture of your situation.


Communicate with your healthcare team to help them understand your goals, concerns, and expectations. This conversation will be useful in getting everyone on the same page.

View Doctor Discussion Guide

XELJANZ (tofacitinib) resource support brochures

Discover RA Support Resources

Whether you want to learn more about XELJANZ or have already been prescribed it for your moderate to severe RA, we can provide you with tools and support resources. We'll start by sending you a Welcome Kit in the mail and follow up with additional communications containing timely information and lifestyle tips.

Sign Up Now

Share Your Story

Share your story and help other adults learn about your experiences with moderate to severe rheumatoid arthritis and XELJANZ. Learning about your experience may be helpful for patients who are considering treatment or have already started.

Share Your Story

If selected, your story may appear on XELJANZ.com and/or in other marketing materials.

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XELJANZ (tofacitinib) 5mg prescription bottle

Easy-To-Open Bottle

The easy-to-open XELJANZ bottle cap has received an Arthritis Foundation Ease-of-Use Certification.

The Arthritis Foundation's Ease of Use Certification recognizes products and packaging, such as the XELJANZ bottle cap, tested and proven to make life
easier for people living with arthritis, chronic pain and functional limitations.

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