Explore A Different Way To Treat Adults With Active Ankylosing Spondylitis (AS)
Taking XELJANZ
5 mg tablets
Two times a day with or without food

Not actual size
Immediate release into the bloodstream over the course of several hours
11 mg extended-release tablets
One time a day with or without food*

Not actual size
Extended release into the
bloodstream over the course
of a day
*XELJANZ XR tablets should be swallowed whole and intact. Do not crush, split, or chew.
When you take XELJANZ XR, you may see something in your stool that looks like a tablet. This is the empty shell from the tablet after the medicine has been absorbed by your body.
If you take too much XELJANZ or
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
Questions About XELJANZ
XELJANZ (tofacitinib) is a prescription medicine called a Janus kinase (JAK) inhibitor used to treat adults with active ankylosing spondylitis when 1 or more tumor necrosis factor (TNF) blocker medicines have been used, and did not work well or cannot be tolerated.
The safety information below applies to all marketed formulations of XELJANZ. Specific risks associated with certain dosing are noted.
Serious infections. XELJANZ can lower the ability of your immune system to fight infections. Do not start taking XELJANZ if you have any kind of infection unless your healthcare provider tells you it is okay. Serious infections have happened in people taking XELJANZ. These serious infections include tuberculosis (TB) and infections caused by bacteria, fungi, or viruses that can spread throughout the body. Some people have died from these infections. Your healthcare provider should test you for TB before starting and during treatment with XELJANZ. You should not start taking XELJANZ if you have any kind of infection unless your healthcare professional tells you it is okay.
Before and after starting XELJANZ, tell your doctor if you are being treated for an infection, have infections that keep coming back, or have symptoms of an infection, including:
- • fever, sweating, or chills
- • cough
- • blood in phlegm
- • warm, red, or painful skin or sores on your body
- • burning when you urinate
- • urinating more often than normal
- • muscle aches
- • shortness of breath
- • weight loss
- • diarrhea or stomach pain
- • feeling very tired
These are not all of the possible side effects of XELJANZ. Learn more and read the Medication Guide.
Before you use XELJANZ, tell your healthcare provider if you:
- • Are being treated for an infection, have an infection that won’t go away or keeps coming back, or think you have symptoms of an infection
- • Have TB, or have been in close contact with someone with TB, or were born in, lived in, or traveled where there is more risk for getting TB
- • Have diabetes, chronic lung disease, HIV, or a weak immune system. People with these conditions have a higher chance for infections
- • Live or have lived in certain areas (such as Ohio and Mississippi River Valleys and the Southwest) where there is an increased chance for getting certain kinds of fungal infections
- • Have or have had Hepatitis B or C
- • Are a current or past smoker
- • Have had any type of cancer
- • Have had a heart attack, other heart problems or stroke
- • Have had blood clots
- • Have liver or kidney problems
- • Have any stomach area (abdominal) pain or been diagnosed with diverticulitis or ulcers in your stomach or intestines
- • Have recently received or plan to receive a vaccine. People taking XELJANZ should not receive live vaccines but can receive non-live vaccines
- • Are pregnant, planning to become pregnant, breastfeeding, or planning to breastfeed. You should not take XELJANZ and breastfeed
- • Have had a reaction to tofacitinib or any of the ingredients
- • Are taking other medicines, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Especially tell your healthcare provider if you take any of the following medicines while taking XELJANZ since this may increase your risk of infection:
- • Tell your healthcare provider if you are taking medicines that affect the way certain liver enzymes work. Ask your healthcare provider if you are not sure if your medicine is one of these.
These are not all of the possible side effects of
If you are a carrier of the Hepatitis B or C virus (viruses that affect the liver), the virus may become active while you use XELJANZ. Your healthcare provider may do blood tests before starting and while using treatment with XELJANZ. Tell your healthcare provider if you have any signs of these symptoms: feel very tired, little or no appetite, clay-colored bowel movements, chills, muscle aches, skin rash, skin or eyes look yellow, vomiting, fevers, stomach discomfort, or dark urine.
Common side effects in people with rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis include upper respiratory tract infections (common cold, sinus infections), headache, diarrhea, nasal congestion, sore throat, and runny nose (nasopharyngitis), and high blood pressure (hypertension).
These are not all of the possible side effects of
Thank You!
We’ve sent a confirmation message to you by email or text (based on your selection), which contains a link and code needed to complete your registration. Simply click the link, enter the code, and agree to the full terms and conditions to receive your XELJANZ Co-Pay Savings Program details.
You’ve also registered to receive information about XELJANZ for AS, so be on the lookout for the materials you requested soon. If you have questions, concerns, or comments, please contact us.
Thank You For Signing Up!
You’ve registered to receive information about XELJANZ for AS, so be on the lookout for the materials you requested soon. If you have questions, concerns, or comments, please contact us.
Thank You!
We’ve sent a confirmation message to you by email or text (based on your selection), which contains a link and code needed to complete your registration. Simply click the link, enter the code, and agree to the full terms and conditions to receive your XELJANZ Co-Pay Savings Program details.
Thank You For Signing Up!
You’ve registered to receive information about XELJANZ for AS, so be on the lookout for the materials you requested soon. If you have questions, concerns, or comments, please contact us.
Savings & Support
Are you starting on treatment with XELJANZ for AS, but you’re concerned about covering the cost? You may be eligible for the XELJANZ Co-Pay Savings Program for commercially insured patients or qualify for other financial support resources to help you access your treatment. Terms and conditions and eligibility requirements apply.
Pay as little as $0 per month for your XELJANZ prescription
† Eligibility required. Annual savings of $6,000–$15,000. Federal and state healthcare beneficiaries ineligible. No membership fee. Offer not valid for cash paying patients. Terms and conditions apply.
Sign up for the XELJANZ Co-Pay Savings Program, if Eligible
Has your doctor prescribed XELJANZ for your AS treatment? Our Co-Pay Savings Program‡ may reduce out-of-pocket cost for eligible, commercially insured patients who have been prescribed XELJANZ for AS. Eligibility requirements apply.

If you are unable to confirm your eligibility or have additional questions, call XELSOURCE at 1-844-935-5269.
‡For eligible underinsured or uninsured patients, XELSOURCE may offer financial assistance through the Pfizer Patient Assistance Program. Call XELSOURCE to learn more about these programs. Terms and conditions/eligibility requirements apply.
For additional support, there’s XELSOURCE
You may need a little extra help getting started after you have been prescribed XELJANZ.
Call XELSOURCE for help:
- Contacting your insurance company on your behalf
- Helping investigate and assess your eligibility for coverage when needed
- Confirming your out-of-pocket costs
- Assisting you with obtaining Prior Authorization (PA)
when needed
- Providing a patient portal at xelsourcepatientportal.com to allow you to monitor the status of your XELJANZ prescription once received by XELSOURCE
A process used by some health insurance companies to determine if they would cover a prescribed medication
Ready to fill your XELJANZ prescription?
To speak to someone at XELSOURCE about your insurance coverage and XELJANZ costs, Monday through Friday, 8:00 AM-8:00 PM ET, call 1-844-935-5269 and say "Representative."
XELJANZ/XELJANZ XR (tofacitinib) is used to treat adults who have tried TNF blockers with:
- Moderately to severely active rheumatoid arthritis when 1 or more medicines called tumor necrosis factor (TNF) blockers have been used, and did not work well or cannot be tolerated
- Active psoriatic arthritis when 1 or more tumor necrosis factor (TNF) blocker medicines have been used, and did not work well or cannot be tolerated
- Moderately to severely active ulcerative colitis when 1 or more tumor necrosis factor (TNF) blocker medicines have been used, and did not work well or cannot be tolerated
- Active ankylosing spondylitis when 1 or more tumor necrosis factor (TNF) blocker medicines have been used, and did not work well or cannot be tolerated
XELJANZ/XELJANZ Oral Solution is used to treat patients 2 years of age and older with:
- Active polyarticular course juvenile arthritis when 1 or more tumor necrosis factor (TNF) blocker medicines have been used, and did not work well or cannot be tolerated
It is not known if XELJANZ/XELJANZ XR is safe and effective in people with Hepatitis B or C.
XELJANZ/XELJANZ XR/XELJANZ Oral Solution is not recommended for people with severe liver problems.
It is not known if XELJANZ/XELJANZ Oral Solution is safe and effective in children for treatment other than active polyarticular course juvenile arthritis.
It is not known if XELJANZ XR is safe and effective in children.
XELJANZ/XELJANZ XR (tofacitinib) is used to treat adults who have tried TNF blockers with:
- Moderately to severely active rheumatoid » Read More
Indications
Important Safety Information

Pay as little as $0 per month for your XELJANZ prescription*
Eligibility required. Annual savings of $6,000–$15,000. Federal and state healthcare beneficiaries ineligible. No membership fee. Offer not valid for cash paying patients. Terms and conditions apply.

Eligibility required. Annual savings of $6,000–$15,000. Federal and state healthcare beneficiaries ineligible. No membership fee. Offer not valid for cash paying patients. Terms and conditions apply.
Sign Up